Barb drives five hours each way to help care for her mother, Irene, who is in the last stages of Alzheimer’s. The family has brought Irene back from a nursing home to their house in rural Wisconsin. Barb’s father, at 80, is the lead caregiver in this family that includes three grown daughters. The family navigates the perils of strained relationships and Irene’s frailty as she slides into her final days. Despite some head-butting with their dad, the sisters carry on with good humor. But deep down, Barb is terrified that she will be next to inherit the disease. DETERMINED follows the Daniels family as they care for Irene as long as they can. Barb joins the WRAP study, and her two sisters are also in the test group. Their father, on the other hand, neglects his own health.