All In: The Human Subjects

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All In:
The Human Subjects



The Story

Three women at high risk for Alzheimer’s disease offer their brains and bodies to a medical study. After losing their mothers to the disease, these daughters are determined to contribute to the search for a cure. Meanwhile, they anxiously watch for signs of the disease in their own brains.

This independent documentary, filmed over five years, intimately shows what happens when human test subjects – who are at high risk for developing Alzheimer’s disease – offer their blood, brains, and hearts to conquer it.

Since Dr. Mark Sager took the initiative in 2001, medical research scientists at the Wisconsin Alzheimer’s Institute at the University of Wisconsin have been on a mission – to figure out how to prevent, and eventually cure, Alzheimer’s disease.

Their method is to track the characteristics and habits of people at high risk for the disease, and to observe them in biological detail as they age. Some convert to Alzheimer’s disease and some do not. Why?

After humble beginnings, the study—the Wisconsin Registry for Alzheimer’s Prevention (WRAP) —is now recognized by the National Institutes of Health as a high-priority research site.

At the heart of the Alzheimer’s study are the test group participants – middle-aged adults with a deceased or living parent with Alzheimer’s disease. Parental history makes the test group 2.5x more likely to get the disease than those without a history of it in their families.

The human research subjects are followed by the scientists for a minimum of 15 to 20 years and undergo periodic and rigorous cognitive tests.

The test group also shares one of life’s most difficult trials – a parent’s decline from Alzheimer’s disease.

This is a story about the fight to stop Alzheimer’s disease as told by the people with the most on the line.




The Characters

Barb, Karen and Sigrid also return every two to three years to undergo the signature experience – a multidisciplinary oral cognitive test. This battery of questions looks for problems with their memory that signal their worst fear—the onset of Alzheimer’s disease.

By combining clinical, brain imaging, biomarker information and physical fitness data, scientists are in pursuit of both the causes of the disease and what lifestyle practices may help delay the onset. It’s a race against time, but thus far, Alzheimer’s has been the victor.

As the researchers compile data from 1,500 participants over the first period of the study, a narrative begins to emerge. 

How soon will an answer be found?

Can it be found in time?

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Therese Barry-Tanner

Therese Barry-Tanner


Therese Barry-Tanner has been a participant in the WRAP study for more than fifteen years. Therese understands Alzheimer’s disease at an intimate level. She assisted her father in caring for her mother with the disease. Later she advocated for her mother fiercely at a nursing home —her mother was unable to speak for herself. Therese lost her mother to Alzheimer’s disease in November of 2008. All In: The Human Subjects began as Therese’s idea in 2011. Therese hopes that All In: The Human Subjects will bring the audience through the emotional journey and difficult decisions that are made when a loved one lives with or dies from Alzheimer’s disease. She also hopes the film will share the experience of being a human research subject, and that it will offer an inside look at the people who are working to find a cure. Prior to producing, Therese worked in healthcare, with over 30 years in program and project management, most recently specializing in healthcare reform and physician quality assurance at a Fortune 500 company.  

Melissa Godoy

Melissa Godoy


Godoy was Line Producer for the 2019 Sundance competition feature documentary American Factory 美国工厂by Steven Bognar & Julia Reichert (Higher Ground Productions, Netflix) and its prequel by the same team, the Oscar-nominated short The Last Truck (HBO). She was also Line Producer for Bognar and Reichert’s Emmy Award-winning documentary, A Lion in the House (Independent Lens). She was the Cincinnati cinematographer for Election Day by Katy Chevigny (POV); a cinematographer for the short docs Making Morning Star and Sparkle (Lifecasters/PBS) both by Bognar & Reichert; and a shooter for Andrea Torrice’s Trees in Trouble (PBS World Channel). Her documentary about creative aging, Do Not Go Gently, co-produced with Eileen Littig, was available to PBS stations for 12 years through American Public Television. For the past seven years Godoy has been shooting The Park, a vérité documentary about change in Cincinnati’s historic core as told from multiple points of view.
Eileen Littig

Eileen Littig


Eileen Littig is an independent producer and former Director of NE Wisconsin In-School Telecommunications. With Wisconsin Public Television, she produced social issues programming and has been recognized with two Midwest Emmys – both for stories about teenage girls: Beyond the Butterfly and The Discovery of Dawn. In 1992 she earned a Gold Medal from the CPB for Sexual Orientation: Between the Labels. Littig was Co-Producer for the documentary Do Not Go Gently, narrated by Walter Cronkite. The film received a Gold World Medal in Humanities from the New York Film and Video Festivals and a National Media Award from the American Society on Aging. Littig serves on the Wisconsin Educational Communications Board and is a community activist.

Shawndra Jones

Shawndra Jones


Jones was a producer/shooter/editor and sound recordist for Reinvention Stories, a collaboration between the National Public Radio station in Yellow Springs, Ohio – WYSO 91.3, led by Neenah Ellis, and filmmakers Steven Bognar and Julia Reichert. In 2012, she was a sound mixer for the short docs Making Morning Star, which premiered at the 2016 Cleveland International Film Festival and Sparkle (Lifecasters/PBS), both by Bognar & Reichert. In 2015 she was on the location sound team for Contemporary Color, a visual and audio extravaganza by the Ross Brothers, which premiered at the Tribeca Film Festival. Jones was the Cincinnati sound engineer for The New Black by Yoruba Richen (Independent Lens/PBS). Jones is a graduate of Wright State University’s Motion Picture Program. She also works at WBDT and WDTN-TV in Dayton.

Amy Kruep

Amy Kruep


Amy Kruep, RNC, DCP has worked with the older adults for more than 30 years, particularly those with Alzheimer’s disease and related dementia. She is a nurse manager for Residential Care at Mercy Health West Park, a continuum care facility in Cincinnati, where she created the DaySTAE (Success Through Arts & Environment) dementia program. Kruep serves on the Alzheimer’s Association Greater Cincinnati Public Policy Committee, and she is a regional trainer for the national TimeSlips™ creative storytelling program. Kruep produced two short fiction films in collaboration with participants in her DaySTAE program: Runaway Train (2010) and with support from the Ohio Arts Council, Until Sadie Blotz (2012). Created by writers and actors with dementia, Sadie screened at the Positive Aging Conference in Los Angeles and the American Society on Aging Conference in Chicago. Amy cared for her father through his last days with Alzheimer’s disease.

Jo Hillman

Jo Hillman


Jo cared for her mom when she was diagnosed with Alzheimer’s disease. After her mother’s death in 2004, Jo became a human test subject in the WRAP study. A post-secondary educator, Jo’s career has taken her to private and public institutions across the U.S. and Canada. She has received awards of excellence for her teaching and quality enhancement initiatives. Jo was Vice President of the National Quality Academy, taking continuous quality improvement concepts to schools of higher education. She is the founding principal of Performance Horizons Consulting Group, which offers quality improvement strategies to post-secondary schools. Jo’s media productions include Connections, a customer service training program for higher education and Keeping the Green in Greenville, about urban forestry in a Wisconsin town.

Karen Y. Durgans

Karen Y. Durgans

Impact Producer

Karen was Associate Producer and Outreach Coordinator for Steven Bognar and Julia Reichert’s A Lion in the House, an Emmy Award-winning documentary and national outreach project (Independent Lens/PBS). Durgans was a field researcher for the U.S. Financial Diaries Project, a research and development partnership between New York University Wagner’s Financial Access Initiative and the Center for Financial Services Innovation out of Chicago. She provided research, logistical and audio support for “American International Health Alliance: Partners in Health,” which profiled international sister-city partnerships in Armavir, Armenia and Galveston, Texas. “Partners in Health” aired in Season 10 of the award-winning PBS series, The Visionaries.

Jean Wentz

Jean Wentz

Production Assistant

Jean worked as an archives assistant at the University of Wisconsin-Green Bay library for 20 years before making a career change. In addition to working on this film, she is now a caregiver for the elderly and those with disabilities, including Alzheimer’s disease and other dementias. Jean is also the administrative assistant for the Green Bay Area Unitarian Universalist Fellowship and Chair of the Sunday Services committee. She is a mandala facilitator in the tradition of Dr. Rajita Sivananda (Judith Cornell), which involved 108 hours of leading workshops.



Center for Independent

The Center for Independent Documentary (CID) collaborates with independent filmmakers to create documentaries on issues of contemporary social and cultural concern. CID is the fiscal sponsor of All In: The Human Subjects and manages the project funds through their 501(c)(3). They bring expertise in fundraising, production, and distribution. Recent CID projects include the recent Netflix-Higher Ground Productions acquisition Crip Camp by Jim LeBrecht & Nicole Newnham, Dawnland by Adam Mazo & Ben Pender-Cudlip, Nancy Kates’ Regarding Susan Sontag (HBO), and Cheryl Furjanic’s Back on Board: Greg Louganis. Founded in 1981, CID’s programs have screened at major festivals, aired nationally and locally on public and cable television, and earned numerous awards.



Alzheimer’s Association

The Greater Wisconsin Chapter aided in securing initial funding for All In: The Human Subjects, which was instrumental to making the project a reality. It is one of over 70 Alzheimer’s Association chapters across the United States and shares the organization’s mission: “To eliminate Alzheimer’s disease through the advancement of research; to provide and enhance care and support for all affected; and to reduce the risk of dementia through the promotion of brain health.”

All In: The Human Subjects is made possible with support from:

  • Bader Philanthropies
  • Recall Foundation
  • Funds of the Greater Green Bay Community Foundation
  • Irene D. Kress
  • The Premonstratensian Fathers Augustine Stewardship Fund
  • Weyers Family Foundation
  • Philip J Hendrickson
  • Marianne Van Drisse
  • Foley Family Foundation
  • Arthur & Hilde Erickson Family LLLP
  • Patricia A. Schneider
  • Wochinske Family Foundation Inc.
  • Jewish Foundation of Greater Dayton
  • Lou Holland Jr.
  • Green Bay Packers Foundation
  • B.L. Smith
  • L.J. Morrison
  • American Foods Group Inc.
  • Daniel & Nancy Gulling
  • Fran ChampmanFrigo
  • Josh & Gisela Brogan
  • C. & P. Tanner
  • L.C. Paul
  • Leander and Helen Schwartz
  • K. A. Jacklin
  • Konop Family Foundation
  • Court & Patricia Larkin
  • Carol R. DeGroot
  • Donald & Jennifer Sipes
  • Judy Nagel
  • Individuals honoring a loved one who died of Alzheimer’s Disease

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